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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Disulfiram is metabolized into copper–diethyldithiocarbamate, which binds to NPL4 and induces its aggregation in cells, leading to blockade of the p97–NPL4–UFD1 pathway and induction of a complex cellular phenotype that results in cell death.
Disulfiram is metabolized into copper–diethyldithiocarbamate, which binds to NPL4 and induces its aggregation in cells, leading to blockade of the p97–NPL4–UFD1 pathway and induction of a complex cellular phenotype that results in cell death.
Issue #2
Article with paywall (only subscribers can read the full research).
- Accepted by admin
- Type of issue
- IV generated for non-target page
- Reported
- Dec 8, 2017